Endocannabinoid system

Endocannabinoid System

The endocannabinoid system can be explained as the body’s internal network of physiological processes governed by signaling molecules that resemble those found in the cannabis plant. These molecules in turn bind to special receptors throughout the human body to regulate a broad range of biological function.​

The “Key and Lock”

  • Every lock has its own key
  • If the key is not precise, the lock does not open
  • The endo-cannabinoid is the key that has to fit the target cell specifically and productively

The “Keys”

Endo-cannabinoids

Endocannabinoids are endogenous compounds produced naturally in the body that bind to cannabinoid receptors. In 1992, researchers detected the first known endocannabinoid. This compound, known as anandamide, comes from the Sanskrit word “Ananda” for bliss and “amide” due to its chemical structure.

Phyto-cannabinoids

Phytocannabinoids, on the other hand, are exogenous compounds that are found in the oily resin of the buds and leaves of plants such as cannabis. The word cannabinoid is used interchangeably for these compounds which work to mimic or counteract the effects of the naturally occurring endocannabinoids.

CBD “Non-Psychoactive” or “Non-Intoxicating”

Cannabidiol has been clinically shown to:

  • Act centrally on the nervous system to reduce seizure frequency
  • Alleviate symptoms of opioid withdrawal
  • Alleviate symptoms of anxiety
  • Elevate mode to lessen symptoms of depression

Therefore, non-psychoactive is by definition misleading because it DOES function within the central nervous system to influence our “psyche.”​

On the other hand, it DOESN’T produce symptoms of impairment or intoxication.

The Entourage Effect

The enhancing, synergistic effect that occurs when the whole plant including cannabinoids, terpenes, and botanical compounds are consumed together.

Routes of Administration

Inhalation

  • Onset of action is rapid, usually within minutes
  • It results in 10%-35% absorption of available THC and other cannabinoids
  • Peak plasma concentration occurs within 8 minutes

Ingestion

  • Onset generally occurs within 1-3 hours but is unpredictable
  • Only 5%-20% is absorbed due to stomach acid content and metabolism
  • Metabolism of Delta 9-THC results in a metabolite, 11 Hydroxy THC that has presumably 5 times the potency and efficacy
  • Peak levels occur 2-6 hours after ingestion

Cannabinoids & Terpenes

There are over 100 known Cannabinoids and over 200 known Terpenes

Cannabidiol CBD Linalool
Tetrahydrocannabinol THC Caryophyllene
Cannabigerol CBG Limonene
Cannabinol CBN Terpineol
Tetrahydrocannabinolic Acid THC-A Eucalyptol
Cannabidiolic Acid CBD-A Pinene
Here’s a list of medical conditions that potentially qualify Missourians to get a medical marijuana card from the state.
Medical conditions not found on the official MO list may still qualify as the state left it up to the doctors judgement.

Navigating Choices: A Guide on How to Choose the Right Cannabis Dispensary in Missouri

Introduction: As the cannabis industry continues to flourish in Missouri, the abundance of dispensaries offers consumers a wealth of choices. However, selecting the right cannabis dispensary can be a daunting task. In this guide, we will explore the key factors to consider when choosing a cannabis dispensary in Missouri, ensuring that your experience aligns with…

Read More

Encyloweedia Bricannabis Bubba Fett

Encyloweedia Bricannabis is Bubba-back with some intel on the differences between smoking cannabis flower and concentrate. I decided to go with a local favorite, Bubba Fett by Flora Farms, an indica dominant hybrid strain named after my favorite bounty hunter and a cross of Bubba Kush x Stardawg. Bubba Fett has remained a top seller…

Read More

Cannabis and Seniors: A Growing Trend in Missouri

Introduction: In recent years, a notable trend has emerged in the landscape of cannabis consumption—seniors are increasingly turning to cannabis for its potential therapeutic benefits. While long-associated with the counterculture, cannabis is undergoing a renaissance, particularly among the elderly population seeking alternative wellness solutions. This blog will explore the rising trend of cannabis use among…

Read More

Unveiling the Surprises: 10 Unexpected Benefits of Cannabis Tinctures and Topicals

Introduction: In the ever-evolving world of cannabis consumption, tinctures and topicals have emerged as discreet and versatile alternatives to traditional methods. Beyond the well-known benefits of cannabis, these formulations offer unique advantages that might surprise many. In this blog, we’ll explore ten unexpected benefits of cannabis tinctures and topicals, shedding light on their potential to…

Read More

Navigating Potency: A Deep Dive into Cannabis Concentrates – Shatter, Wax, and Live Resin

In the evolving landscape of cannabis consumption, the diversity of available products has expanded dramatically, offering consumers a plethora of options to explore. Among the many choices, cannabis concentrates have gained immense popularity for their potent effects and versatility. In this comprehensive guide, we will delve into three prominent cannabis concentrates – Shatter, Wax, and…

Read More

Unlocking Wellness: 10 Benefits of Cannabis Microdosing for a Balanced Lifestyle

Introduction: Cannabis has long been associated with various therapeutic properties, and as research continues to advance, new methods of consumption are emerging. One such method gaining popularity is cannabis microdosing, a practice that involves taking small, controlled amounts of cannabis to achieve subtle therapeutic effects without the intense psychoactive experiences associated with larger doses. In…

Read More

Unlocking Wellness: The Benefits of Incorporating CBD into Your Daily Routine

Introduction: In recent years, CBD (cannabidiol) has gained significant attention for its potential health benefits. Derived from the cannabis plant, CBD is a non-psychoactive compound that interacts with the endocannabinoid system, contributing to various physiological processes. As more people explore natural alternatives for overall well-being, incorporating CBD into daily routines has become a popular choice.…

Read More

Cannabis and Pain Management: A Comprehensive Overview

Introduction: In the realm of alternative medicine, cannabis has emerged as a versatile and intriguing option for pain management. As societal perceptions shift and legalization gains momentum, exploring the relationship between cannabis and pain relief becomes increasingly relevant. This blog provides a comprehensive overview of cannabis as a potential ally in the complex landscape of…

Read More

Unveiling the Winning Formula for Sleep: CBD with CBN, THC, and Melatonin

Introduction: In the realm of holistic wellness, the pursuit of a good night’s sleep often leads individuals to explore alternative solutions. Cannabidiol (CBD), cannabinol (CBN), tetrahydrocannabinol (THC), and melatonin have emerged as key players in the quest for better sleep. In this blog, we delve into the synergy of CBD with CBN, THC, and melatonin,…

Read More

THCV and Vape Pens: The Perfect Pairing for Cannabis Enthusiasts

Introduction: Cannabis enthusiasts are always on the lookout for innovative and convenient ways to experience the diverse benefits of cannabinoids. In recent years, a particular cannabinoid has been gaining attention for its unique properties – Tetrahydrocannabivarin (THCV). When it comes to consumption methods, vape pens have emerged as a popular choice among cannabis users. In…

Read More

THCV and Eczema: A Natural Approach to Soothing Skin Irritation

Introduction: Eczema, a chronic skin condition characterized by inflammation and irritation, affects millions of individuals worldwide. While various treatments are available, emerging research suggests that Tetrahydrocannabivarin (THCV), a lesser-known cannabinoid, may offer a natural and promising approach to soothing the discomfort associated with eczema. In this blog post, we will explore the potential benefits of…

Read More

Infused Edibles: A Growing Trend in Cannabis Manufacturing

Infused edibles are indeed a growing trend in the cannabis manufacturing industry. They refer to food and beverage products that have been infused with cannabis compounds, such as THC (tetrahydrocannabinol) and CBD (cannabidiol). This trend has gained significant popularity for several reasons: Variety of Products: Infused edibles come in a wide range of products, including…

Read More